A compound in broccoli and kale helps suppress tumour growth.


ISLAMABAD -- Researchers from Harvard Medical School's Beth Israel Deaconess Medical Center in Boston, MA, saw that the compound indole-3- carbinol (I3C) impeded tumour-growth in a mouse model of prostate cancer. In a Science study paper, they explain that I3C promotes PTEN, a tumour suppressor protein "whose activity is often decreased in human cancers." The team found a molecular pathway in which the protein WWP1 alters and weakens the tumour suppressor PTEN. WWP1 is active in several human cancers. However, their investigation reveals that I3C can inactivate WWP1 by switching off its gene. This unleashes the full power of PTEN to restrict tumour growth.

"We found a new important player that drives a pathway critical to the development of cancer," says...

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