Akeso Reported 2022 Annual Results.

HONG KONG: Akeso Inc. (HKEX Code: 9926.HK, "Akeso", or the "Company") released its 2022 annual report. During the reporting period, the company enjoyed booming business development and made breakthrough progress in drug innovation and development, commercialization and internationalization.

Kai Tan Ni (r)(cadonilimab, PD-1/CTLA-4 bispecific antibody)saw a strong start

With excellent safety and efficacy profile, a well-established commercialization platform and great efforts by the highly productive sales force, Kai Tan Ni (r) recorded strong sales of RMB546.3 million for the financial year ended December 31, 2022.

On June 29, 2022, Kai Tan Ni (r) , the first-in-class PD-1/CTLA-4 bi-specific antibody independently developed by the company, has been granted marketing approval by the NMPA for the treatment of recurrent or metastatic cervical cancer (R/M CC) patients who have progressed on or after platinum-based chemotherapy. Kai Tan Ni (r) is the first approved dual immune checkpoint inhibitor bispecific antibody globally, addressing a huge unmet medical need for immunotherapy for advanced cervical cancer in China, and is also pioneering the development of bispecific antibodies in China.

An Ni Ke (r)(penpulimab injection, PD-1), jointly developed by Akeso and Sino Biopharmaceutical Limited (stock code: 1177.HK), recorded product sales of RMB558.1 million in 2022, increasing 164%. In April 2022, three indications were included in the 2022 CSCO Guideline, which are penpulimab for treatment of refractory/relapsed classic Hodgkin Lymphoma (r/r cHL), penpulimab in combination with chemotherapy as first-line treatment of squamous NSCLC, penpulimab as secondline treatment or salvage treatment of recurrent/metastatic nasopharyngeal carcinoma (r/m NPC). In January 2023, An Ni Ke (r) in combination with chemotherapy as first-line treatment of locally advanced or metastatic squamous non-small cell lung cancer was approved by NMPA.

Expediting global collaboration and development signified by landmark outlicensing transaction of ivonescimab (PD-1/VEGF, AK112)

Another breakthrough development was overseas licensing which set a new record for the transaction amount of a single innovative drug in China. In December 2022, exclusive development licensing rights were granted to Summit Therapeutics in the United States, Canada, Europe and Japan for ivonescimab, a breakthrough PD-1/VEGF bispecific antibody independently developed by Akeso. Akeso has received an...